Manuela Neumann Selected Research

Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)

1/2022	Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
1/2021	Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases.
1/2019	Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
1/2018	Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.
12/2017	Fused in Sarcoma Neuropathology in Neurodegenerative Disease.
1/2017	Reappraisal of TDP-43 pathology in FTLD-U subtypes.
4/2016	Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
1/2016	Frontotemporal dementia: from molecular mechanisms to therapy.
1/2016	Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies.
7/2015	Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

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Manuela Neumann Research Topics

Disease

52	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2022 - 06/2005
34	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 10/2006
27	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 10/2006
17	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 11/2009
13	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 12/2004
9	Alzheimer Disease (Alzheimer's Disease) 10/2014 - 01/2003
9	Dementia (Dementias) 04/2014 - 01/2003
7	Parkinson Disease (Parkinson's Disease) 01/2012 - 11/2002
5	Multiple System Atrophy 01/2013 - 06/2002
5	Motor Neuron Disease (Primary Lateral Sclerosis) 02/2009 - 07/2007
4	TDP-43 Proteinopathies 02/2009 - 07/2007
3	Disease Progression 01/2016 - 06/2004
3	Ewing Sarcoma (Sarcoma, Ewing) 11/2012 - 09/2011
3	Muscular Diseases (Myopathy) 06/2010 - 02/2007
3	Osteitis Deformans (Paget's Disease of Bone) 06/2010 - 02/2007
3	Tauopathies 06/2008 - 06/2004
3	Synucleinopathies 10/2006 - 11/2002
2	Neuroinflammatory Diseases 01/2020 - 11/2007
2	Pathologic Processes 01/2020 - 09/2011
2	Cytomegalovirus Infections (Inclusion Disease) 11/2011 - 11/2009
2	Parkinsonian Disorders (Parkinsonism) 01/2011 - 03/2005
2	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 06/2010 - 05/2010
2	Cognitive Dysfunction 02/2009 - 09/2007
2	Pick Disease of the Brain (Pick's Disease) 06/2005 - 06/2004
2	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 04/2005 - 08/2003
1	Vesicular Stomatitis 10/2021
1	Ataxia (Dyssynergia) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Seizures (Absence Seizure) 01/2020
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2020
1	Amyloid Plaque 01/2020
1	Angelman Syndrome (Syndrome, Angelman) 10/2014
1	Amyloidosis 10/2014
1	Body Weight (Weight, Body) 04/2014
1	Proteostasis Deficiencies 09/2011
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2011
1	Autism Spectrum Disorder 05/2010
1	Intellectual Disability (Idiocy) 05/2010
1	Down Syndrome (Down's Syndrome) 12/2009

Drug/Important Bio-Agent (IBA)

38	Proteins (Proteins, Gene)FDA Link 10/2021 - 06/2004
25	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022 - 02/2007
17	UbiquitinIBA 01/2017 - 06/2005
12	ProgranulinsIBA 01/2018 - 03/2007
10	alpha-SynucleinIBA 03/2008 - 06/2002
8	RNA-Binding Protein FUSIBA 12/2017 - 11/2009
7	DNA (Deoxyribonucleic Acid)IBA 04/2016 - 03/2008
6	Valosin Containing ProteinIBA 06/2010 - 02/2007
6	AntibodiesIBA 02/2009 - 06/2004
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2012
5	Karyopherins (Importin)IBA 04/2016 - 08/2010
4	Biological ProductsIBA 01/2018 - 01/2003
4	RNA-Binding Proteins (RNA-Binding Protein)IBA 04/2016 - 09/2011
3	TATA-Box Binding Protein (TATA-Binding Protein)IBA 11/2012 - 09/2011
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 09/2012 - 04/2006
2	Protein AggregatesIBA 10/2021 - 10/2010
2	RNA (Ribonucleic Acid)IBA 01/2021 - 11/2009
2	Serine (L-Serine)FDA Link 01/2021 - 11/2020
2	Amyloid (Amyloid Fibrils)IBA 01/2020 - 10/2014
2	SynucleinsIBA 01/2016 - 01/2013
2	Arginine (L-Arginine)FDA Link 09/2013 - 11/2012
2	Nuclear Proteins (Protein, Nuclear)IBA 09/2013 - 11/2012
2	Coloring Agents (Dyes)IBA 11/2009 - 10/2006
2	Monoclonal AntibodiesIBA 10/2006 - 04/2006
2	Endopeptidase K (Proteinase K)IBA 12/2004 - 11/2002
2	Peptides (Polypeptides)IBA 08/2003 - 01/2003
2	Amyloid beta-PeptidesIBA 08/2003 - 01/2003
1	PrionsIBA 10/2021
1	LigandsIBA 10/2021
1	Glycoproteins (Glycoprotein)IBA 10/2021
1	poly(glycyl-alanyl)IBA 01/2020
1	DipeptidesIBA 01/2020
1	HLA-DQA2 antigenIBA 01/2019
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 04/2016
1	Formaldehyde (Formol)FDA Link 10/2014
1	Ataxin-2IBA 10/2014
1	A Kinase Anchor ProteinsIBA 05/2014
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 05/2014
1	Messenger RNA (mRNA)IBA 09/2013
1	MethyltransferasesIBA 09/2013
1	Proline (L-Proline)FDA Link 11/2012
1	Tyrosine (L-Tyrosine)FDA Link 11/2012
1	Nuclear Localization Signals (Nuclear Localization Signal)IBA 11/2012
1	Poly(A)-Binding Proteins (Poly(A)-Binding Protein)IBA 06/2012
1	alpha 1-Antitrypsin (alpha 1 Antitrypsin)IBA 01/2012
1	NeurotoxinsIBA 01/2011
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2011
1	TOR Serine-Threonine KinasesIBA 01/2011
1	Complement System Proteins (Complement)IBA 07/2010
1	Protons (Proton)IBA 05/2010
1	SodiumIBA 05/2010
1	P-2 (P 2)IBA 03/2010
1	Flavin-Adenine Dinucleotide (FAD)IBA 12/2009
1	Hematoxylin (Haematoxylon)IBA 11/2009
1	Eosine Yellowish-(YS) (Eosin)IBA 11/2009
1	alpha-internexinIBA 11/2009
1	CaspasesIBA 08/2009

Therapy/Procedure

3	Therapeutics 01/2021 - 03/2005
1	Euthanasia (Mercy Killing) 01/2020
1	Muscle Denervation 01/2020
1	Aftercare (After-Treatment) 01/2016